Understanding the MTHFR gene: why it matters for your health

Understanding the MTHFR gene: why it matters for your health

By Innate Biology - supporting your genes, naturally

If you’ve ever felt like your body is more sensitive to stress, has trouble detoxifying, or struggles with low energy, mood swings, or hormonal imbalances, your genes could be playing a role - particularly a gene called MTHFR.

At Innate Biology, we believe in empowering people through genetic knowledge and natural support. Today, we're diving into the MTHFR gene: what it does, why it matters, and how you can support it with lifestyle, food, and targeted supplementation.

What is the MTHFR gene?

MTHFR stands for methylenetetrahydrofolate reductase, a key enzyme in your body’s methylation pathway. This pathway is like a biological switchboard that helps regulate:
  • Detoxification
  • DNA repair
  • Neurotransmitter balance (e.g., serotonin, dopamine)
  • Energy production
  • Hormone metabolism
  • Cardiovascular function
  • Immune response
In simple terms, MTHFR helps convert folate (vitamin B9) into its active form, 5-MTHF (5-methyltetrahydrofolate), which is essential for the methylation process to run smoothly.

What happens when the MTHFR gene has a variant?

Some people inherit a MTHFR gene variant (SNP) that slows down this conversion process. The most well-studied variants are:
  • C677T
  • A1298C

You can have:

  • One copy (heterozygous) – mild impact
  • Two copies (homozygous) – moderate to significant impact
Having one or both of these variants can reduce the MTHFR enzyme’s activity by 30% to 70%, depending on your combination. This can impair methylation and lead to a build-up of homocysteine (an inflammatory marker), and reduce your ability to produce S-adenosylmethionine (SAMe), which supports mood, focus, and detoxification.
Potential health issues associated with MTHFR variants

While having a MTHFR SNP doesn’t guarantee illness, it may increase your risk, especially when combined with poor diet, chronic stress, or toxin exposure.
 

Some associated conditions include:

  • Chronic fatigue and low energy
  • Hormonal imbalances (e.g., PMS, infertility, miscarriage)
  • Anxiety, depression, or brain fog
  • Poor detoxification or chemical sensitivity
  • Cardiovascular issues (elevated homocysteine)
  • Autism spectrum or ADHD (in some cases)
  • Autoimmune disorders
  • Migraines or headaches
  • Fibromyalgia or chronic pain
How to support the MTHFR gene naturally
1. Choose active B vitamins
Support your body by giving it nutrients in the forms it can use without extra conversion:Folate (B9): 5-MTHF (methylfolate), not folic acid B12: Methylcobalamin or Hydroxycobalamin, not cyanocobalamin B6: P5P (Pyridoxal-5-Phosphate)

2. Eat folate-rich foods (not folic acid!)

Focus on leafy greens and whole foods like:

  • Spinach, kale, rocket
  • Avocados
  • Broccoli
  • Asparagus
  • Lentils and beans
  • Beets
  • Liver (in moderation)
3. Reduce environmental toxins

MTHFR variants may reduce your ability to detox. Minimize exposure to:

  • Pesticides
  • BPA and plastics
  • Heavy metals
  • Chemical-laden skincare
  • Balance Stress & Sleep

Methylation is sensitive to stress hormones. Practice:

  • Breathwork
  • Meditation or prayer
  • Movement (yoga, walking, strength)
  • Quality sleep (7–9 hours)
5. Test and supplement wisely

If you know you have a MTHFR variant, consider working with a practitioner to:

  • Test homocysteine and methylation markers
  • Supplement with a high-quality methylation support formula
At Innate Biology, we are formulating gentle, effective supplements that cater to MTHFR variants - starting with active B12 lozenges to support energy, mood, and methylation.

How to find out if you have the MTHFR variant

You can test your genetics using:

  • A practitioner-based DNA test (e.g., MTHFR Support Australia, SmartDNA)
  • Consumer options like 23andMe or MyDNA (then analyse with tools like Genetic Genie or NutraHacker)
Final thoughts: your genes aren’t your destiny
Your genes are blueprints, not life sentences. Even with a MTHFR mutation, you can thrive by giving your body the right tools.

Understanding your MTHFR gene helps you:

  • Personalise your diet and supplements
  • Reduce the risk of chronic issues
  • Feel more energised, clear, and balanced
If you're ready to explore your genes and support your biology from the inside out, we’re here to help. 
Coming Soon from Innate Biology: personalised gene support packages and MTHFR friendly supplements

Stay tuned!
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